Floor Plate Derived Tissues

1 developmental biology program sloan kettering institute 1275 york ave new york ny 10065 usa.

Floor plate derived tissues.

Little is known about human fp development due the lack of tissue accessibility. The floor plate fp is a critical signaling center during neural development located along the ventral midline of the embryo. The floor plate fp is a critical signaling center during neural development located along the ventral midline of the embryo. Located on the ventral midline of the embryonic neural tube the floor plate is a specialized glial structure that spans the anteroposterior axis from the midbrain to the tail regions it has been shown that the floor plate is conserved among vertebrates such as zebrafish and mice with homologous.

Here we report the efficient derivation of human embryonic stem cell hesc derived fp tissue capable of secreting netrin 1 and shh and patterning primary and hesc derived tissues. The study efficient derivation of functional floor plate tissue from human embryonic stem cells was published in the online edition of cell stem cell on april 1 2010 and will also appear in. Fasano ca 1 chambers sm lee g tomishima mj studer l. Here we report the efficient derivation of.

Efficient derivation of functional floor plate tissue from human embryonic stem cells.