Floor Plate Cues

These cells partition the distance traveled by growing axons into shorter intervals by serving as intermediate targets orchestrating the arrival and departure of axons by providing attractive and repulsive guidance cues.

Floor plate cues.

Cues are additionally presented at intermediate points that lie along the axonal trajectory effectively partition ing the pathway of a developing axon into a series of intermediate targets that orchestrate axonal arrival and departure 3. The floor plate in the central nervous system cns is a critical intermediate target during neuronal development required. The floor plate is a structure integral to the developing nervous system of vertebrate organisms. Lyuksyutova et al 2003.

Longitudinal axons project through the same environment and thus are potentially influenced by the same floor plate cues albeit resulting in distinct trajectories. Summarized by de ramon francàs et al 2017. We decided to screen for differentially expressed floor plate genes as candidate guidance cues directing commissural axons along the. Same floor plate cues albeit resulting in distinct trajectories.

Additional floor plate signals dictate the direction of turns after crossing bourikas et al 2005. 15 the response to a netrin 1 gradient in vitro also depends. When axons arrive at the floor plate short range guidance cues take over. Xenopus spinal neurons lose their attraction to netrin 1 following exposure to slit a guidance cue that like netrin 1 is secreted by the floor plate.

A canonical example of a critical inter mediate target is the floor plate fp which resides at. The floor plate repels cultures of longitudinal axons in vitro tamada et al 1995 while certain longitudinal axon bundles wander into the midline in zebrafish lacking floor plate hatta 1992. Located on the ventral midline of the embryonic neural tube the floor plate is a specialized glial structure that spans the anteroposterior axis from the midbrain to the tail regions it has been shown that the floor plate is conserved among vertebrates such as zebrafish and mice with homologous. Axons have been shown to enter the floor plate as a result of interactions between axonal contactin 2 also known as axonin and neuronal cell adhesion molecule nrcam in the floor plate stoeckli and landmesser 1995.

In the mouse floor plate several wnts particularly wnt4 and wnt7b are expressed in a rostral high to caudal low gradient. A candidate guidance cue for postcommissural axons. Was more compact and closest to the floor plate and therefore most likely to be influenced by floor plate cues.